Immuno-Oncology Cell-Based Assays

Creative Bioarray provides comprehensive immuno-oncology cell-based assays to help understand the relationship between immune system and tumor microenvironment, and accelerate the development of I-O drugs.

Introduction of Immuno-Oncology

Under normal circumstances, immune system plays a vital role in protecting human body from harmful substances. However, sometimes cancer can weaken the immune system or avoid the destruction by immune attack. This is the main obstacle in designing effective anticancer therapies. Oncologists have increasingly turned their attention to immuno-oncology.

Figure 1. Integration of immunoediting and oncogenesis during cancer progression. (Prendergast G C., 2008)

Immuno-oncology (I-O) is a branch of immunology, which studies the pathogenesis, prevention, diagnosis and treatment of cancer based on the ability of the immune system to search for, assess, and eliminate foreign substances from the body. It aims to enable the immune system to recognize and respond to harmful cells by providing tools to unmask tumors. These novel treatments that take advantage of the immune system to fight cancer are called I-O therapies. The rapid development of I-O therapy has changed the pattern of cancer treatment.

Figure 2. Small-molecule drug targets to restore cancer immunity in the tumour. (Adams J L, et al., 2015)

The Power of Immuno-Oncology Cell-Based Assays

• Play an important role in the study of tumor antigenicity, the relationship between immune function and tumorigenesis, the immune response against tumor, and the mechanism of anti-tumor immunity.
• Provide an early-stage platform to facilitate the progress of early drug discovery, from target identification to lead optimization.
• Help to fill the gap between in vitro screening and in vivo models.
• Immuno-oncology cell-based assays based on high-throughput platform enables scientists to rapidly assess the immunomodulatory function of potential therapies.

Our Immuno-Oncology Cell-Based Assays

Cell Function Assays

We can provide a complete set of cell function assays for immuno-oncology research to help reveal the relationship of immune system and cancer cells. Co-culture and 3D models are also available to better mimic the tumor microenvironment.

Cell-Type-Specific Assays

We can provide cell-type-specific assays for specific types of immune cells (such as T cells, dendritic cells, macrophages, natural killer cells) and tumor cells to accurately evaluate the recognition and killing effect of immune cells on tumor.

Featured Platforms

Based on state-of-the-art technology, our experienced scientific team has established several featured platforms, including high-throughput, high-content, and live-cell imaging, to help promote the development of I-O therapy.

Creative Bioarray can provide customized services to meet the specific needs of our customers. You will benefit from our high-quality services with fast turnaround time and competitive price. If you need more detailed information, please feel free to contact us. We look forward to cooperating with you.

References:

1. Prendergast G C. Immune escape as a fundamental trait of cancer: focus on IDO. Oncogene, 2008, 27(28): 3889.
2. Adams J L, et al. Big opportunities for small molecules in immuno-oncology. Nature reviews Drug discovery, 2015, 14(9): 603.
3. Finn O J. Immuno-oncology: understanding the function and dysfunction of the immune system in cancer. Annals of oncology, 2012, 23(supplement 8), pp: viii6-viii9.