Creative Bioarray provides quality control tests for customized media or customer-defined media formulations. This service can help customers quickly test the performance of media and shorten the development cycle of customized media. With years of service experience in biological and chemical analysis, we are confident to provide you with competitive advantages.
Every type of cell culture is unique, and the correct cell culture medium helps a lot. Commercial culture media may sometimes not fully meet the specific cell culture needs of customers, which leads to customized culture media. The optimization of components in cell culture media is critical to performance. Design of experiments and a large number of protein and small-molecule product combinations to generate helpful customized formulations of culture media require further component analysis to ensure product safety. We provide a series of customized media quality control related testing services, which can help customers test and analyze the impact of customized media on the growth, expansion, and differentiation of specific cell types. This service can also help speed up and standardize media production, develop optimized media formulations, and conduct special media testing.
Our expertise includes media and supplement composition analysis, media formulation optimization recommendations, and use for testing media on stem cells, immune cells, and other cell lines. We provide comprehensive tests to evaluate sterility, bioburden, composition, performance, etc. Feedback your needs to us, and our quality control laboratory will be responsible for the rest of the testing work.
Micronutrient analysis. In addition to the macronutrients that support cell growth, the influence of mineral elements and microorganisms in the medium on cell growth should not be underestimated. The trace minerals in the culture medium usually include additives and other raw materials. The influence of trace elements in other raw materials is potentially toxic to some specific cells and needs to be accurately measured. This service tests nearly 20 trace elements in finished culture media and cell culture raw materials to achieve quality control purposes. The key quality control of dozens of trace elements such as Chromium, Copper, Iron, Selenium, Zinc in the finished product and raw materials. At the same time, we also provide an assay of the content of water-soluble vitamins.
Toxicity analysis. This part is mainly for the analysis of some toxins in the culture medium that have hidden biological safety hazards and affect cell growth. This part of the test includes a comprehensive USP sterility test and analysis of some viruses and toxins. We analyze the bioburden in the sample by determining the approximate colony-forming unit (CFU) in the test medium sample and analyze the specific biochemical markers related to mycoplasma to determine the presence of endotoxin in the medium. In addition, we also provide virus antibody scanning tests in samples (such as HCV virus, HIV virus, hepatitis B virus, etc.).
Analysis of media components for specific cells. This service is mainly carried out for culture media with specific functions or purposes, helping customers determine the influence of culture media on the growth or differentiation of specific cells. For example, analysis of the influence of culture media and/or reagents used for neuron culture on the growth performance of biological cells.
Nutritional analysis. The routine test of the culture medium mainly focuses on the analysis of the basic function of culture-supporting growth-related aspects. These aspects include the determination of the active ingredients or potency of the product, the analysis of the impact on cell viability, cell growth test, pH, osmotic pressure, solubility. At the same time, it also includes the analysis of some important components, such as amino acid analysis, ethanolamine quantification.
Fig 1. Quality control analysis of cell culture media.
Methodology. Our media quality control service platform uses a variety of methods for analysis, such as high school liquid chromatography, LC-MS/MS, conventional chemical staining, immunological testing. According to the differences in the molecules to be tested according to customer needs, we have formed a time-efficient solution. Our expert team has many years of experience in analysis and testing services, and we are confident to provide you with first-class services.
Creative Bioarray's biological and chemical analysis platform can provide component analysis and basic function testing services for customized media. This service is designed to help customers verify the scientificity of the test media preparation method. You will benefit from the analysis platform, and our expert team will provide you with the best solution.
If you are interested in our services or have any specific needs, please feel free to contact us. We look forward to working with you in the near future.