Cytotoxicity Assays

Creative Bioarray provides cytotoxicity assays to determine the number of viable and dead cells in a cell population after treatment with compounds, pharmaceutical substances or other stimuli to assess the effect on cell viability. We offer cell-based high-content cytotoxicity screening services to help in drug screening and toxicity evaluation. Our professional services can help you accelerate the process of drug discovery and development.

About Cytotoxicity

Cytotoxicity refers to the ability of agents or cells to destroy living cells. Cells exposed to a cytotoxic agent can respond in many ways, such as necrosis and apoptosis. Understanding the mechanisms involved in cytotoxicity can help researchers to better understand the biological processes of cell growth, cell proliferation and death.

Cytotoxicity assays are valuable tools to accurately measure cytotoxicity of compounds. They provide a sensitive, rapid and validated approach to analyze the toxic effects on cellular systems. Cytotoxicity assays are widely used in fundamental research and drug discovery process. Measuring cell cytotoxicity is of vital importance for the identification of candidates with potential health risks to human body in the development of new pharmaceutical products. It also proves to be quite indispensable in the process of developing therapeutic anticancer drugs.

Silver nanoparticles-induced cytotoxicity.Figure 1. Silver nanoparticles-induced cytotoxicity. (Akter M, et al., 2018)

Cytotoxicity Assays at Creative Bioarray

Multiple cytotoxicity assays are available at Creative Bioarray to monitor various toxicity markers. Cell viability assays, such as colorimetric assays, dye exclusion assays and fluorometric assays, can be used to determine cytotoxicity. We also provide services for the following different types of cytotoxicity:

Mitotoxicity

Mitochondrial membrane potential, reactive oxygen species or calcium flux can be measured to monitor mitochondrial function, which is an important parameter in cytotoxicity.

Lipotoxicity

Toxic agents may trigger phospholipidosis which a lysosomal storage disorder, and steatosis which is the abnormal retention of lipids.

Cardiotoxicity

Cardiotoxicity is the main reason for drug discontinuation and failure of clinical trials. Early assessment of cardiotoxicity is of great significance for drug development.

Hepatotoxicity

Liver is mainly involved in metabolism. It is a preferred target for drug toxicity. Hepatotoxicity is another main reason for drug withdrawal.

Neurotoxicity

A number of drug candidates can cause neurotoxicity at the therapeutic level. Estimating the neurotoxic potential is of great concern for their impact on human health.

Nephrotoxicity

The kidney is regarded as a major target for toxic agents. Drug-induced neophrotoxicity is increasingly considered to be a prominent cause of kidney diseases.

Genotoxicity

Evaluate the alterations to the integrity and function of genetic materials is an important indicator of cytotoxicity. DNA damage is the main manifestation of genotoxicity.

Other Cytotoxicity

Other targeted cytotoxicity assays can also be carried out according to your specific requirements.

Creative Bioarray is committed to providing rapid, sensitive and customized cytotoxicity assays to meet the specific needs of our customers in fundamental research and drug development projects. Our experienced scientific team can customize the best solutions. We also offer a range of products for cytotoxicity assays.

If you are interested in our services or products, please feel free to contact us. We look forward to cooperating with you.

References:

  1. Akter M, et al.  A systematic review on silver nanoparticles-induced cytotoxicity: Physicochemical properties and perspectives. Journal of advanced research, 2018, 9, pp: 1-16.
  2. Niles A L, et al. Update on in vitro cytotoxicity assays for drug development. Expert opinion on drug discovery, 2008, 3(6), pp: 655-669.
  3. Corbo C, et al. The impact of nanoparticle protein corona on cytotoxicity, immunotoxicity and target drug delivery. Nanomedicine, 2016, 11(1), pp: 81-100.
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As a pioneer of biotechnology, Creative Bioarray has developed into one of the largest independent biotechnology companies in the world. We are committed to providing our customers with innovative high-quality products and services through discovering, developing, and manufacturing.

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