Tumor necrosis factor (TNF) is a protein hormone produced by leukocytes, which has various biological activities and is involved in many physiological and pathological processes. TNF mainly acts on tumor cells and inflammatory tissues at the site of infection, inducing apoptosis of tumor cells, increasing the activity of the immune system, and causing inflammatory responses in the body. In some diseases, such as rheumatoid arthritis and inflammatory bowel disease, TNF exacerbates the inflammatory response by inducing immune cell activity and cytokine release, leading to the progression and exacerbation of the disease.

Creative Bioarray has successfully developed a wide range of cytokine products and other reagents, and has accumulated more than 10 years of development and manufacturing experience. Our TNFs are used in a wide range of biological applications, including but not limited to

• Cytotoxicity studies: TNF has been found to be lethal to cancer cells, so it can be used to study the sensitivity and resistance of different cell types to TNF, and also to study the synergistic effects of TNF with other cytokines such as IL-1 and IFN-γ.
• Immunological research: TNF can promote the proliferation and differentiation of T cells, B cells, and macrophages, as well as enhance cell-mediated immune responses, cytokine production, and cell surface antigen presentation, etc. Therefore, it can be applied to study immune regulation and other aspects.
• Research on tumor therapy: TNF can also be used as a selective killer of tumor cells, to investigate the growth and reproduction pattern of tumor cells in in vitro culture, and to provide research direction and basis for tumor therapy.
• Inflammatory response research: TNF is an important inflammatory factor that can be involved in regulating inflammatory response, so it can be applied to the study of inflammation-related diseases.