Chroman 1

Product Code: GFC0659

Catalog Number	Unit Size	Price
GFC0659-10 mg	10 mg	Online Inquiry
GFC0659-50 mg	50 mg	Online Inquiry

Description

Chroman 1 is a highly potent and selective ROCK2 (Rho-kinase) inhibitor. Chroman 1 promotes survival of pluripotent stem cells (PSCs) in culture when used in combination with Emricasan, Polyamine Supplement, and trans-ISRIB, a combination known as CEPT. When used as part of the CEPT cocktail, Chroman 1 also improves survival of differentiated cells following cryopreservation with cardiomyocyte cell survival increasing by 36% and motor neuron survival improving by 63% compared with DMSO controls.

Specification

Chemical Name

(3S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2H-1-benzopyran-3-carboxamide dihydrochloride

Formula

C24H28N4O4.2HCl

Molecular Weight

509.43

Purity

≥98% (HPLC)

InChi Key

ROFMCPHQNWGXGE-SFHVURJKSA-N

SMILES String

COC1=CC=C2OC[C@@H](C(NC3=C(C=C(C4=CNN=C4)C=C3)OCCN(C)C)=O)CC2=C1.Cl.Cl

Storage

Store at -20°C. Store under desiccating conditions.

For research or further manufacturing use only. Not for use in humans.