TNF superfamily member 13b (TNF13B) is part of the tumor necrosis factor (TNF) superfamily and is expressed by monocytes, macrophages, dendritic cells, and neutrophils. TNF13B signaling activates the NF-kB signaling pathway, and promotes B cell survival, Ig class switching, and antigen presentation. TNF13B also has functions in other cell types: it promotes monocyte survival and activation, proinflammatory cytokine secretion, and differentiation into macrophages, and co-stimulates anti-CD3-mediated activation of human T cells.
