Cytokines

Rat TNF

Product Code: GFC0158

Description

Tumor necrosis factor (TNF, also known as TNF-α) is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. TNF-α has cytotoxic effects on cancer cells in vitro by stimulating anti-tumor immunosuppressive responses. TNF-α stimulates expression of E- and P-selectins, thus facilitating adhesion of neutrophils, monocytes, and memory T cells to activated platelets and endothelial cells.

Specification

Source

P. pastoris

Symbols

Cachectin, Cytotoxin, Differentiation-inducing factor, DIF, Necrosin, TNFA, TNFSF2, Tumor necrosis factor

Accession

P16599

AA Sequence

MLRSSSQNSSDKPVAHVVANHQAEEQLEWLSQRANALLANGMDLKDNQLVVPADGLYLIYSQVLFKGQGCPDYVLLTHTVSRFAISYQEKVSLLSAIKSPCPKDTPEGAELKPWYEPMYLGGVFQLEKGDLLSAEVNLPKYLDITESGQVYFGVIAL

Molecular Mass

17.4 kDa

Purity

≥ 95%

Bioactivity

The specific activity as determined by a cytotoxicity assay using L929 cells in the presence of actinomycin D is ≥ 2.0 x 10^7 units/mg (EC50 ≤ 0.05 ng/mL).

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.