Cytokines

Mouse TNF10

Product Code: GFC0155

Description

Tumor necrosis factor (ligand) superfamily, member 10 (TNF10) belongs to the tumor necrosis factor (TNF) superfamily and is associated with initiating apoptosis. TNF10 binds to the death receptors, which recruits the Fas-associated death domain (FADD) and activates caspases 8 and 10, which eventually leads to apoptosis.

Specification

Source

E. coli

Symbols

TL2, TNF-related apoptosis-inducing ligand, TNFSF10

Accession

P50592

AA Sequence

GRGGRPQKVAAHITGITRRSNSALIPISKDGKTLGQKIESWESSRKGHSFLNHVLFRNGELVIEQEGLYYIYSQTYFRFQEAEDASKMVSKDKVRTKQLVQYIYKYTSYPDPIVLMKSARNSCWSRDAEYGLYSIYQGGLFELKKNDRIFVSVTNEHLMDLDQEASFFGAFLIN

Molecular Mass

20 kDa

Purity

≥ 95%

Bioactivity

The specific activity as determined by the ability to inhibit RPMI-8226 cell proliferation is ≥ 1.0 x 10^4 units/mg (EC50 ≤ 100 ng/mL).

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.