Cytokines

Human TNF

Product Code: GFC0153

Description

Tumor necrosis factor (TNF) is a pro-inflammatory cytokine that activates NF-kB, MAPK, and PI3K/AKT pathways. TNF has cytotoxic effects on cancer cells in vitro by stimulating anti-tumor immuno- suppressive responses. TNF stimulates expression of E- and P-selectins, thus facilitating adhesion of neutrophils, monocytes, and memory T cells to activated platelets and endothelial cells.

Specification

Source

E. coli

Symbols

DIF-alpha, TNFA, TNFSF2, TNLG1F, TNF

Accession

P01375

AA Sequence

MVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

Molecular Mass

17.5 kDa

Purity

≥ 95%

Bioactivity

The specific activity as determined by the cytolysis of mouse L929 cells growing in the presence of actinomycin D is ≥ 5 x 10^5 units/mg (EC50 ≤ 2 ng/mL).

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.