Cytokines

Human PDGFD

Product Code: GFC0142

Description

Platelet-derived growth factor D (PDGFD) is a member of the platelet-derived growth factor family. It has been shown that PDGF-induced migration involves signaling pathways involving MEK/ERK, EGFR, Src and PI3K/AKT. PDGF is a potent mitogen for cells of mesenchymal origin such as fibroblasts and vascular smooth muscle cells. PDGF has been implicated in pathogenesis of atherosclerosis, glomerulonephritis, cancer, and in the contraction of vascular smooth muscle cells of rat aortic tissues.

Specification

Source

CHO

Symbols

IEGF, Platelet-derived growth factor D, SCDGFB, MSTP036

Accession

Q9GZP0

AA Sequence

SYHDRKSKVDLDRLNDDAKRYSCTPRNYSVNIREELKLANVVFFPRCLLVQRCGGNCGCGTVNWRSCTCNSGKTVKKYHEVLQFEPGHIKRRGRAKTMALVDIQLDHHERCDCICSSRPPR

Molecular Mass

14.0 kDa

Purity

≥ 95%

Bioactivity

The specific activity as determined by a cell proliferation assay using 3T3 cells is ≥ 2.0 x 10^2 units/mg (EC50 ≤ 5 μg/mL).

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.