Cytokines

Human PDGFC

Product Code: GFC0141

Description

Platelet-derived growth factor C (PDGFC) is a member of the platelet-derived growth factor family. It has been shown that PDGF-induced migration involves signaling pathways involving MEK/ERK, EGFR, Src and PI3K/AKT. PDGF is a potent mitogen for cells of mesenchymal origin such as fibroblasts and vascular smooth muscle cells. PDGF has been implicated in pathogenesis of atherosclerosis, glomerulonephritis, cancer, and in the contraction of vascular smooth muscle cells of rat aortic tissues.

Specification

Source

HEK293

Symbols

PDGF, Platelet-derived growth factor

Accession

NP_057289

AA Sequence

VVDLNLLTEEVRLYSCTPRNFSVSIREELKRTDTIFWPGCLLVKRCGGNCACCLHNCNECQCVPSKVTKKYHEVLQLRPKTGVRGLHKSLTDVALEHHEECDCVCRGSTGG

Molecular Mass

12.5 kDa

Purity

≥ 95%

Bioactivity

The specific activity as determined by a cell proliferation assay using 3T3 cells is ≥ 1.0 x 10^6 units/mg (EC50 ≤ 1 ng/mL).

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.