Mouse PDGFB

Product Code: GFC0140

Description

Platelet-derived growth factor (PDGF) is a dimeric glycoprotein consisting of two disulfide bridge-stabilized polypeptide chains, A and B, which are assembled as heterodimers (PDGF-AB) or homodimers (PDGF-AA and PDGF-BB). PDGF is a potent mitogen for cells of mesenchymal origin, such as fibroblasts, glial cells, and vascular smooth muscle cells. PDGF has been implicated in pathogenesis of atherosclerosis, glomerulonephritis, cancer, and in the contraction of vascular smooth muscle cells of rat aortic tissues.

Specification

Source
E. coli
Symbols
GDGF, ODGF, Platelet-derived growth factor
Accession
P31240
AA Sequence
MSLGSLAAAEPAVIAECKTRTEVFQISRNLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRASQVQMRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETIVTPRPVT
Molecular Mass
12.4 kDa monomer; 24.6 kDa dimer
Purity
≥ 95%
Bioactivity
The specific activity as determined by a cell proliferation assay using BALB/c 3T3 cells is ≥ 5 x 10^5 units/mg (EC50 ≤ 2 ng/mL).
Storage
Store at -80°C. Avoid repeated freeze-thaw cycles.
For research or further manufacturing use only. Not for use in humans.

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