Cytokines

Human NTF4

Product Code: GFC0135

Description

Neurotrophin 4 (NTF4) is a member of the nerve growth factor family which includes neurotrophin 3 (NTF3), brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF), all of which promote the differentiation, growth, and survival of peripheral and central nervous system neurons. NTF4 acts as a survival factor for certain populations of sensory neurons. It has been shown that NTF4, together with BDNF, promotes neurite extension and maturation, as well as maintenance of differentiated cerebellar granule cells.

Specification

Source

E. coli

Symbols

GLC10, GLC1O, Neutrophic factor 4, Neutrophic factor 5, Neurotrophin-5, NT-4/5, NT-5, NTF4, NT4, NT5, NTF5

Accession

P34130

AA Sequence

MGVSETAPASRRGELAVCDAVSGWVTDRRTAVDLRGREVEVLGEVPAAGGSPLRQYFFETRCKADNAEEGGPGAGGGGCRGVDRRHWVSECKAKQSYVRALTADAQGRVGWRWIRIDTACVCTLLSRTGRA

Molecular Mass

14.0 kDa monomer; 28.1 kDa dimer

Purity

≥ 95%

Bioactivity

The specific activity as determined by a cell proliferation assay using C6 cells is ≥ 3.3 x 10^2 units/mg (EC50 ≤ 3.0 μg/mL).

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.