Cytokines

Human LTA

Product Code: GFC0126

Description

Lymphotoxin alpha (LTA, also known as TNFB), is a member of the TNF family. It is a pro-inflammatory cytokine that activates NF-kB, MAPK, and PI3K/AKT pathways upon binding to TNF receptors 1 and 2. It is involved in autoimmune disorders, lymph node development, and mediating the inflammatory demyelination process.

Specification

Source

E. coli

Symbols

LT, TNFB, TNFSF1, TNLG1E

Accession

P01374

AA Sequence

MLPGVGLTPSAAQTARQHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPSTVFFGAFAL

Molecular Mass

18.8 kDa

Purity

≥ 95%

Bioactivity

The specific activity as determined by the cytolysis of mouse L929 cells growing in the presence of actinomycin D is ≥ 2.5 x 10^8 units/mg (EC50 ≤ 0.004 ng/mL).

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.