Human LIF

Product Code: GFC0123

Description

Leukemia inhibitory factor (LIF) is an interleukin 6 class cytokine that regulates a broad variety of developmental functions. LIFR activation of STAT3 is essential for maintaining the mouse embryonic stem cell phenotype. Produced by the endometrium, LIF plays an important autocrine and paracrine role in implantation by regulating proliferation, invasion, and differentiation of trophoblasts following blastocyst attachment.

Specification

Source
E. coli
Symbols
CDF, Cholinergic differentiation factor, D Factor, DIA, Differentiation-inducing factor, Differentiation inhibitory activity, Differentiation-stimulating factor, Emfilermin, Hepatocyte-stimulating factor III, HILDA, Leukemia inhibitory factor, MLPLI
Accession
P15018
AA Sequence
SPLPITPVNATCAIRHPCHNNLMNQIRSQLAQLNGSANALFILYYTAQGEPFPNNLDKLCGPNVTDFPPFHANGTEKAKLVELYRIVVYLGTSLGNITRDQKILNPSALSLHSKLNATADILRGLLSNVLCRLCSKYHVGHVDVTYGPDTSGKDVFQKKKLGCQLLGKYKQIIAVLAQAF
Molecular Mass
19.7 kDa
Purity
≥ 95%
Bioactivity
The specific activity as determined by a cell differentiation assay using TF-1 cells is ≥ 5 x 10^6 units/mg (EC50 ≤ 0.2 ng/mL).
Storage
Store at -80°C. Avoid repeated freeze-thaw cycles.
For research or further manufacturing use only. Not for use in humans.

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