Human KITLG, animal component-free

Product Code: GFC0119

Description

KIT ligand (KITLG, also known as SCF) is an early-acting cytokine that plays a pivotal role in the regulation of embryonic and adult hematopoiesis. SCF promotes cell survival, proliferation, differentiation, adhesion, and functional activation of cells at multiple levels of the hematopoietic hierarchy. Together with other cytokines such as thrombopoietin and Flt3/Flk-2 Ligand, SCF is commonly used to promote expansion of primitive hematopoietic stem cells and multi-potent progenitor cells in culture. In synergy with various growth factors, including IL-2, IL-3, IL-6, IL-7, G-CSF, and erythropoietin, SCF increases proliferation and differentiation of myeloid and erythroid progenitor cells and a subset of lymphoid progenitor cells. SCF is also a primary growth and activation factor for mast cells and eosinophils.

Specification

Source
E. coli
Symbols
DCUA, DFNA69, FPH2, FPHH, KL-1, Kitl, MGF, SCF, SF, SHEP7, SLF, WS2F
Accession
P21583
AA Sequence
MEGICRNRVTNNVKDVTKLVANLPKDYMITLKYVPGMDVLPSHCWISEMVVQLSDSLTDLLDKFSNISEGLSNYSIIDKLVNIVDDLVECVKENSSKDLKKSFKSPEPRLFTPEEFFRIFNRSIDAFKDFVVASETSDCVVSSTLSPEKDSRVSVTKPFMLPPVA
Molecular Mass
18.6 kDa
Purity
≥ 95%
Bioactivity
The specific activity as determined by a cell proliferation assay using TF-1 cells is ≥ 6.7 x 10^4 units/mg (EC50 ≤ 15 ng/mL).
Storage
Store at -80°C. Avoid repeated freeze-thaw cycles.
For research or further manufacturing use only. Not for use in humans.

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