Human INHBA, animal component-free

Product Code: GFC0117

Description

Inhibin subunit beta A (INHBA) is a member of the transforming growth factor beta (TGF-β) family of proteins produced by many cell types throughout development. It is a disulfide-linked homodimer (two beta-A chains) that binds to heteromeric complexes of a type I (Act RI-A and Act RI-B) and a type II (Act RII-A and Act RII-B) serine-threonine kinase receptor. Activins primarily signal through SMAD2/3 proteins to regulate a variety of functions, including cell proliferation, differentiation, wound healing, apoptosis, and metabolism. INHBA maintains the undifferentiated state of human embryonic stem cells and also facilitates differentiation of human embryonic stem cells into definitive endoderm.

Specification

Source
E. coli
Symbols
Activin beta-A chain, EDF, Erythroid differentiation protein, FRP, FSH-releasing protein, INHBA, Inhibin betaA chain, Inhibin beta-1
Accession
P08476
AA Sequence
MGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS
Molecular Mass
13.1 kDa monomer; 26.2 kDa dimer
Purity
≥ 95%
Bioactivity
The EC50 as determined by a cell proliferation assay using MPC-11 cells is ≤ 10 ng/mL.
Storage
Store at -80°C. Avoid repeated freeze-thaw cycles.
For research or further manufacturing use only. Not for use in humans.

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