Human IL-21, animal component-free

Product Code: GFC0092

Description

Interleukin 21 (IL-21) is a pleiotropic cytokine that is composed of four α-helical bundles and primarily produced by natural killer T (NKT) cells, T follicular helper (Tfh) cells, and Th17 cells. IL-21 has been shown to have a critical role in regulating immunoglobulin production and differentiation of the pro-inflammatory Th17 population of cells. Additionally, IL-21 specifically sustains CD8+ T cell effector activity and provides a mechanism of CD4+ T cell help during chronic viral infection. IL-21 signaling was also found critical for the development of type 1 diabetes in NOD mice and control of T cell autoimmunity by regulatory B cells.

Specification

Source
E. coli
Symbols
Interleukin-21, Za11
Accession
Q9HBE4
AA Sequence
MQDRHMIRMRQLIDIVDQLKNYVNDLVPEFLPAPEDVETNCEWSAFSCFQKAQLKSANTGNNERIINVSIKKLKRKPPSTNAGRRQKHRLTCPSCDSYEKKPPKEFLERFKSLLQKMIHQHLSSRTHGSEDS
Molecular Mass
15.4 kDa
Purity
≥ 95%
Bioactivity
The specific activity as determined by a cell proliferation assay using B9 cells is ≥ 2.0 x 10^4 units/mg (EC50 ≤ 50 ng/mL).
Storage
Store at -80°C. Avoid repeated freeze-thaw cycles.
For research or further manufacturing use only. Not for use in humans.

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