Human IL-11

Product Code: GFC0075

Description

Interleukin 11 (IL-11) is a pleiotropic cytokine with effects on various tissues including the bone marrow, brain, and intestinal mucosa. It belongs to the IL-6 family of cytokines that share a common signal transducer, gp130. IL-11 induces the proliferation of hematopoietic stem cells and megakaryocytic progenitor cells, the maturation of megakaryocytes, and the production of platelets. IL-11 also plays a role in cancer progression by inducing the proliferation of epithelial cancer cells and the survival of metastatic cells at distant organs.

Specification

Source
E. coli
Symbols
Adipogenic inhibitory factor, AGIF, Interleukin-11, Oprelvekin, IL-11
Accession
P20809
AA Sequence
MPGPPPGPPRVSPDPRAELDSTVLLTRSLLADTRQLAAQLRDKFPADGDHNLDSLPTLAMSAGALGALQLPGVLTRLRADLLSYLRHVQWLRRAGGSSLKTLEPELGTLQARLDRLLRRLQLLMSRLALPQPPPDPPAPPLAPPSSAWGGIRAAHAILGGLHLTLDWAVRGLLLLKTRL
Molecular Mass
19.3 kDa
Purity
≥ 95%
Bioactivity
The specific activity as determined by a cell proliferation assay using TF-1 cells is ≥ 1.0 x 10^5 units/mg (EC50 ≤ 10 ng/mL).
Storage
Store at -80°C. Avoid repeated freeze-thaw cycles.
For research or further manufacturing use only. Not for use in humans.

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