Cytokines

Human GDNF

Product Code: GFC0058

Description

Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor and a member of the tumor growth factor (TGF)-beta superfamily. GDNF is known to promote survival and morphological differentiation of midbrain dopaminergic neurons in both in vivo and in vitro studies and increases their high-affinity dopamine uptake. GDNF has also been shown to have restorative effects on dying dopaminergic neurons in response to degenerative toxins.

Specification

Source

E. coli

Symbols

Astrocyte-derived trophic factor, ATF, ATF1, ATF2, Glial cell-derived neurotrophic factor, HFB1-GDNF, HSCR3

Accession

P39905

AA Sequence

MSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI

Molecular Mass

15.2 kDa monomer; 30.4 kDa dimer

Purity

≥ 95%

Bioactivity

The specific activity as determined by a cell proliferation assay using C6 cells is ≥ 3.3 x 10^2 units/mg (EC50 ≤ 3 μg/mL).

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.