Cytokines

Human GDF11

Product Code: GFC0056

Description

Growth differentiation factor 11 (GDF11) is a member of transforming growth factor beta (TGF-β) family. It binds to the TGF-β receptors ALK4, ALK5, and ALK7 and activates the SMAD signaling pathway. GDF11 regulates the development of the olfactory system, retina, and pancreas, as well as anterior/posterior patterning of the axial skeleton. GDF-11 is an endocrine factor expressed in skeletal muscle, brain, and dental pulp.

Specification

Source

E. coli

Symbols

BMP-11, Bone morphogenetic protein 11, Growth differentiation factor 11, BMP11, VHO

Accession

O95390

AA Sequence

NLGLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS

Molecular Mass

12.5 kDa monomer; 24.9 kDa dimer

Purity

≥ 95%

Bioactivity

The specific activity as determined by an alkaline phosphatase assay using ATDC-5 cells is ≥ 1.0 x 10^4 units/mg (EC50 ≤ 100 ng/mL).

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.