Cytokines

Human FST

Product Code: GFC0055

Description

Follistatin (FST), a glycosylated monomeric protein, is a modulator of transforming growth factor beta (TGF-β) superfamily signaling. It binds to and inhibits the function of activin, myostatin, growth differentiation factors, and bone morphogenetic proteins (BMP). FST inhibits mesoderm induction, suppresses synthesis and secretion of pituitary follicle-stimulating hormone, regulates liver regeneration, and causes infertility.

Specification

Source

E. coli

Symbols

Follistatin, FS, FSH-suppressing protein, FSP

Accession

P19883

AA Sequence

MGNCWLRQAKNGRCQVLYKTELSKEECCSTGRLSTSWTEEDVNDNTLFKWMIFNGGAPNCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSCN

Molecular Mass

31.7 kDa

Purity

≥ 95%

Bioactivity

The specific activity as determined by neutralization of human activin A-induced cytotoxicity of MPC-11 cells is ≥ 5.0 x 10^3 units/mg (EC50 ≤ 0.20 μg/mL).

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.