Cytokines

Mouse CCL4

Product Code: GFC0012

Description

C-C motif chemokine ligand 4 (CCL4) is a member of the CC family of chemokines and is most closely related to CCL3. CCL4, CCL3, and CCL5 have been shown to be major HIV-suppressive factors, possibly through the interactions of these chemokines with the receptor CCR5 on CD4+ T cells, which is also a major receptor for HIV entry into CD4+ T cells. In addition to its chemotactic functions, CCL4 induces the release of proinflammatory cytokines, mast cell degranulation, and NK cell activation.

Specification

Source

E. coli

Symbols

ACT-2, Immune activation protein 2, LAG-1, Lymphocyte activation gene 1 protein, MIP-1b, Protein H400, SCYA2, SCYA4, Small-inducible cytokine A4, T-cell activation protein 2

Accession

Q5QNV9

AA Sequence

APMGSDPPTSCCFSYTSRQLHRSFVMDYYETSSLCSKPAVVFLTKRGRQICANPSEPWVTEYMSDLELN

Molecular Mass

7.8 kDa

Purity

≥ 95%

Bioactivity

The biological activity as determined by a cell migration assay using THP-1 cells is ≤ 100 ng/mL.

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.