Cytokines

Human CCL2

Product Code: GFC0009

Description

C-C motif chemokine ligand 2 (CCL2) is a member of the CC family of chemokines. The biological effects of CCL2 are mediated via the specific G-protein-coupled receptor CCR2 which in turn activates signal transduction pathways leading to monocyte transmigration. CCL2 plays a role in physiological processes such as neurogenesis, neuroprotection, and neurotransmission and has important implications in neurological disorders such as multiple sclerosis and Alzheimer's disease, in which it is produced during neuroinflammation at the sites of lesions.

Specification

Source

E. coli

Symbols

DIA, Differentiation-inducing factor, HILDA, Human interleukin in DA cells, Leukemia inhibitory factor, MCAF, Melanoma-derived LPL inhibitor, MLPLI, Monocyte chemoattractant protein 1

Accession

P13500

AA Sequence

QPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT

Molecular Mass

8.7 kDa

Purity

≥ 95%

Bioactivity

The biological activity as determined by a cell migration assay of THP-1 cells is ≤ 100 ng/mL.

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.