Cytokines

Human BMP2

Product Code: GFC0005

Description

Bone morphogenetic protein 2 (BMP2) is a member of the transforming growth factor beta (TGF-β) superfamily. BMP2 acts as a ligand for complexes of type I and II BMP receptors, and primarily activates SMAD1/5/8 signaling. BMP2 is a potent differentiation factor and directs human pluripotent stem cells (hPSCs) towards various cell types including extra-embryonic endoderm, mesenchymal cells, and chondrocytes.

Specification

Source

E. coli

Symbols

BDA2, BMP-2A, BMP2, Bone morphogenetic protein 2A

Accession

P12643

AA Sequence

MQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR

Molecular Mass

13 kDa monomer; 26.1 kDa dimer

Purity

≥ 95%

Bioactivity

The specific activity as determined by an alkaline phosphatase assay using ATDC-5 cells is ≥ 4.0 x 10^3 units/mg (EC50 ≤ 250 ng/mL).

Storage

Store at -80°C. Avoid repeated freeze-thaw cycles.

For research or further manufacturing use only. Not for use in humans.