Human/Mouse SUZ12 Antibody, Unconjugated

Product Code: CB0908

Catalog Number	Unit Size	Price
CB0908-25 ug	25 ug	Online Inquiry
CB0908-100 ug	100 ug	Online Inquiry

Description

SUZ12, also known as CHET9, JJAZ1 or KIAA0160, belongs to the VEFS family. It is a polycomb group (PcG) protein. SUZ12 is a component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors.

Specification

Reactivity

Human, Mouse

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Clone Number

448909

Label

Unconjugated

Source

E. coli-derived recombinant human SUZ12, Thr131-Asn305, Accession # Q15022

Specificity

Detects human SUZ12 in direct ELISAs and Western Blots.

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Small pack size is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Application

Western Blot; Immunoprecipitation; Immunocytochemistry

Full Name

Suppressor of Zeste 12 Homolog

Alternative Names

ChET 9 protein; CHET9; CHET9polycomb protein SUZ12; Chromatin precipitated E2F target 9 protein; JJAZ1; JJAZ1Joined to JAZF1 protein; KIAA0160Suppressor of zeste 12 protein homolog; suppressor of zeste 12 homolog (Drosophila); SUZ12

Entrez Gene IDs/Gene IDs

23512 (Human); 52615 (Mouse)

Endotoxin

<0.10 EU/μg by the LAL method.

Storage

At -20°C for one year. After reconstitution , at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

For research or further manufacturing use only. Not for use in humans.