Product Code: CB0871
| Catalog Number | Unit Size | Price |
|---|---|---|
| CB0871-50 ug | 50 ug | Online Inquiry |
Description
Lefty was originally discovered while screening undifferentiated cell-specific cDNAs from P19 mouse embryonal carcinoma cells. Its mRNA expression on the left side of the developing embryo earned it the name "lefty". Two genes exist in mouse (Lefty-1 and Lefty-2) and two in humans (Lefty-A (ebaf) and Lefty-B).
Lefty protein is novel TGF-beta ligand that functions as an antagonist of Nodal signaling. The Lefty contains some of the features of the cysteine-knot structure conserved among TGF-beta-related proteins, but also some structural differences. Specifically, they lack the alpha-helical segment important for ligand dimerization as well as the cysteine residue involved in stabilization of dimers. In all species examined, lefty protein functions in patterning left-right asymmetry of the developing organ systems such as the heart and lung. Lefty acts as an antagonist to Nodal signaling, potentially by competing for binding to a common receptor.
Specification
