Human EpCAM/TROP-1 Antibody, PE-conjugated

Product Code: CB0854

Catalog Number	Unit Size	Price
CB0854-100 Tests	100 Tests	Online Inquiry

Description

EpCAM (Epithelial Cellular Adhesion Molecule) is a pan-epithelial differentiation antigen expressed on almost all cancers as 17-1A (mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. EpCAM is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy. EpCAM recently received increased attention as a prognostic factor in breast cancer.

Specification

Reactivity

Human

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Label

Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Source

Mouse myeloma cell line NS0-derived recombinant human EpCAM/TROP-1, Gln24-Lys265, Accession # CAA32870

Specificity

Detects human EpCAM/TROP-1 in direct ELISAs and Western Blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) ALCAM, rhBCAM, rhMCAM, rhNCAM L1, and recombinant mouse OCAM is observed.

Purification

Antigen Affinity-purified

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Application

Flow Cytometry

Full Name

Epithelial Cell Adhesion Molecule

Entrez Gene IDs/Gene IDs

4072 (Human); 17075 (Mouse); 171577 (Rat); 102123042 (Cynomolgus Monkey)

Endotoxin

<0.10 EU/μg by the LAL method.

Storage

At 2 - 8°C for one year. Protect from light.

For research or further manufacturing use only. Not for use in humans.