Human EpCAM/TROP-1 Antibody, Unconjugated

Product Code: CB0849

Catalog Number	Unit Size	Price
CB0849-25 ug	25 ug	Online Inquiry
CB0849-100 ug	100 ug	Online Inquiry
CB0849-500 ug	500 ug	Online Inquiry

Description

EpCAM (Epithelial Cellular Adhesion Molecule) is a pan-epithelial differentiation antigen expressed on almost all cancers as 17-1A (mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. EpCAM is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy. EpCAM recently received increased attention as a prognostic factor in breast cancer.

Specification

Reactivity

Human

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Clone Number

158210

Label

Unconjugated

Source

Mouse myeloma cell line NS0-derived recombinant human EpCAM/TROP-1, Gln24-Lys265, Accession # P16422

Specificity

Detects human EpCAM/TROP-1 in direct ELISAs and Western Blots. This antibody detects an epitope found in the extracellular domain between amino acids 136 and 265. In direct ELISAs and Western Blots, no cross-reactivity with recombinant human (rh) ALCAM, rhBCAM, rhMCAM, rhNCAM-L1, or recombinant mouse (rm) OCAM is observed. In direct ELISAs, less than 5% cross-reactivity with rmEpCAM/TROP-1 is observed.

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Small pack size is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Application

Western Blot; Immunohistochemistry; Immunocytochemistry

Full Name

Epithelial Cell Adhesion Molecule

Entrez Gene IDs/Gene IDs

4072 (Human); 17075 (Mouse); 171577 (Rat); 102123042 (Cynomolgus Monkey)

Endotoxin

<0.10 EU/μg by the LAL method.

Storage

At -20°C for one year. After reconstitution , at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

For research or further manufacturing use only. Not for use in humans.