Human EpCAM/TROP‑1 Antibody, Biotinylated

Product Code: CB0848

Catalog Number	Unit Size	Price
CB0848-50 ug	50 ug	Online Inquiry

Description

EpCAM (Epithelial Cellular Adhesion Molecule) is a pan-epithelial differentiation antigen expressed on almost all cancers as 17-1A (mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. EpCAM is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy. EpCAM recently received increased attention as a prognostic factor in breast cancer.

Specification

Reactivity

Human

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Label

Biotin

Source

Mouse myeloma cell line NS0-derived recombinant human EpCAM, Gln24-Lys265, Accession # CAA32870

Specificity

Detects human EpCAM/TROP-1 in sandwich immunoassays and Western Blots. In sandwich immunoassays, less than 0.2% cross-reactivity with recombinant human (rh) ALCAM, rhBCAM, recombinant mouse MAdCAM-1, rhNCAM-1, and rhNCAM-L1 is observed.

Purification

Antigen Affinity-purified

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Application

Western Blot; Flow Cytometry; ELISA

Full Name

Epithelial Cell Adhesion Molecule

Entrez Gene IDs/Gene IDs

4072 (Human); 17075 (Mouse); 171577 (Rat); 102123042 (Cynomolgus Monkey)

Endotoxin

<0.10 EU/μg by the LAL method.

Storage

At -20°C for one year. After reconstitution , at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

For research or further manufacturing use only. Not for use in humans.