Human EpCAM/TROP-1 Antibody, Unconjugated

Product Code: CB0847

Catalog Number	Unit Size	Price
CB0847-25 ug	25 ug	Online Inquiry
CB0847-100 ug	100 ug	Online Inquiry

Description

EpCAM (Epithelial Cellular Adhesion Molecule) is a pan-epithelial differentiation antigen expressed on almost all cancers as 17-1A (mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. EpCAM is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy. EpCAM recently received increased attention as a prognostic factor in breast cancer.

Specification

Reactivity

Human

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Label

Unconjugated

Source

Mouse myeloma cell line NS0-derived recombinant human EpCAM/TROP-1, Gln24-Lys265, Accession # CAA32870

Specificity

Detects human EpCAM/TROP-1 in direct ELISAs and Western Blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human TROP-2 and approximately 26% cross-reactivity with recombinant mouse EpCAM/TROP-1 is observed.

Purification

Antigen Affinity-purified

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Small pack size is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Application

Western Blot; Simple Western; Flow Cytometry; Immunohistochemistry; CyTOF-ready; Immunocytochemistry

Full Name

Epithelial Cell Adhesion Molecule

Alternative Names

17-1A; 323/A3; ACSTD1; antigen identified by monoclonal AUA1; CD326 antigen; CD326; Cell surface glycoprotein Trop-1; chromosome 4, surface marker (35kD glycoprotein); DIAR5; EGP; EGP-2; EGP314; EGP40; EpCAM; epithelial cell adhesion molecule; Epithelial cell surface antigen; Epithelial glycoprotein 314; Epithelial glycoprotein; ESA; GA733-2; GA733-2EGP34; gp40; hEGP314; HNPCC8; KS 1/4 antigen; KS1/4; KSAHEA125; M1S2; M4S1; M4S1Ly74; Major gastrointestinal tumor-associated protein GA733-2; MIC18MH99; MOC31; TACST-1; TACSTD1; TROP1; TROP1CD326; Tumor-associated calcium signal transducer 1CO-17A

Entrez Gene IDs/Gene IDs

4072 (Human); 17075 (Mouse); 171577 (Rat); 102123042 (Cynomolgus Monkey)

Endotoxin

<0.10 EU/μg by the LAL method.

Storage

At -20°C for one year. After reconstitution , at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

For research or further manufacturing use only. Not for use in humans.