Human DNMT3B Antibody, Unconjugated

Product Code: CB0840

Catalog Number	Unit Size	Price
CB0840-25 ug	25 ug	Online Inquiry
CB0840-100 ug	100 ug	Online Inquiry

Description

DNMT3B is a DNA-(cytosine C5)-methyltransferase that is responsible for establishing the methylation patterns in cooperation with DNMT3A through the de novo methylation pathway. It is essential for the establishment of DNA methylation patterns during development. DNMT3B contains a C-terminal catalytic domain and an N-terminal regulatory domain, which are involved in targeting chromatin to regulate its function.

Specification

Reactivity

Human

Clonality

Polyclonal

Host

Sheep

Isotype

IgG

Label

Unconjugated

Source

E. coli-derived recombinant human DNMT3B, Ser145-Pro355, Accession # Q9UBC3

Specificity

Detects human DNMT3B in direct ELISAs and Western Blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human DNMT3A is observed.

Purification

Antigen Affinity-purified

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Small pack size is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Application

Western Blot; Simple Western; Immunocytochemistry; Knockout Validated

Full Name

DNA [Cytosine-5-]-Methyltransferase 3B

Alternative Names

DNA (cytosine-5-)-methyltransferase 3 beta; DNA (cytosine-5)-methyltransferase 3B; DNA methyltransferase HsaIIIB; DNA MTase HsaIIIB; DNMT3B; EC 2.1.1.37; ICF; ICF1; M.HsaIIIB

Entrez Gene IDs/Gene IDs

1789 (Human); 13436 (Mouse); 444985 (Rat)

Endotoxin

<0.10 EU/μg by the LAL method.

Storage

At -20°C for one year. After reconstitution , at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

For research or further manufacturing use only. Not for use in humans.