Human Cripto-1 Antibody, APC‑conjugated

Product Code: CB0839

Catalog Number	Unit Size	Price
CB0839-100 Tests	100 Tests	Online Inquiry

Description

Cripto-1 (teratocarcinoma-derived growth factor-1) is the original member of EGF-cripto-1-FRL-1-cryptic (CFC) family of vertebrate signaling molecules which is essential for embryonic development and it implicates in carcinogenesis also. Cripto1 functions as a co-receptor for NODAL (TGF-beta member) and is essential for mesoderm as well as endoderm formation and anterior-posterior and left-right axis establishment. After executing key functions during embryonic development, it dramatically disappears in adult tissues (except stem cells). Moreover, in adult life it gets re-expressed in several type of tumors wherein it promotes cell proliferation, migration, invasion, EMT, and angiogenesis.

Specification

Reactivity

Human

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Clone Number

89633

Label

Allophycocyanin (Excitation= 620-650 nm, Emission= 660-670 nm)

Source

E. coli-derived recombinant human Cripto-1, Arg38-Tyr188, Accession # P13385

Specificity

Detects human Cripto-1 in ELISAs. In sandwich immunoassays, no cross-reactivity with recombinant mouse Cripto-1, recombinant human (rh) EGF, rhTGF-alpha, rhTGF-beta 1, rhTGF-beta 2, rhTGF-beta 3, or rhCryptic is observed.

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Application

Flow Cytometry

Full Name

Teratocarcinoma-derived Growth Factor/Cripto Growth Factor

Alternative Names

CFC-2; CR; Cripto; Cripto-1 growth factor; Cripto-1; CRIPTOCRGF; Epidermal growth factor-like cripto protein CR1; TDGF1; TDGF-1; teratocarcinoma-derived growth factor 1

Entrez Gene IDs/Gene IDs

6997 (Human); 21667 (Mouse)

Endotoxin

<0.10 EU/μg by the LAL method.

Storage

At 2 - 8°C for one year. Protect from light.

For research or further manufacturing use only. Not for use in humans.