Human Cripto-1 Antibody, Biotinylated

Product Code: CB0838

Catalog Number	Unit Size	Price
CB0838-50 ug	50 ug	Online Inquiry

Description

Cripto-1 (teratocarcinoma-derived growth factor-1) is the original member of EGF-cripto-1-FRL-1-cryptic (CFC) family of vertebrate signaling molecules which is essential for embryonic development and it implicates in carcinogenesis also. Cripto1 functions as a co-receptor for NODAL (TGF-beta member) and is essential for mesoderm as well as endoderm formation and anterior-posterior and left-right axis establishment. After executing key functions during embryonic development, it dramatically disappears in adult tissues (except stem cells). Moreover, in adult life it gets re-expressed in several type of tumors wherein it promotes cell proliferation, migration, invasion, EMT, and angiogenesis.

Specification

Reactivity

Human

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Label

Biotin

Source

E. coli-derived recombinant human Cripto-1, Arg38-Tyr188, Accession # P13385

Specificity

Detects human Cripto-1 in Western Blots.

Purification

Antigen Affinity-purified

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Application

Western Blot

Full Name

Teratocarcinoma-derived Growth Factor/Cripto Growth Factor

Alternative Names

CFC-2; CR; Cripto; Cripto-1 growth factor; Cripto-1; CRIPTOCRGF; Epidermal growth factor-like cripto protein CR1; TDGF1; TDGF-1; teratocarcinoma-derived growth factor 1

Entrez Gene IDs/Gene IDs

6997 (Human); 21667 (Mouse)

Endotoxin

<0.10 EU/μg by the LAL method.

Storage

At -20°C for one year. After reconstitution , at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

For research or further manufacturing use only. Not for use in humans.