Human/Primate Cripto-1 Antibody, Biotinylated

Product Code: CB0837

Catalog Number	Unit Size	Price
CB0837-250 ug	250 ug	Online Inquiry

Description

Cripto-1 (teratocarcinoma-derived growth factor-1) is the original member of EGF-cripto-1-FRL-1-cryptic (CFC) family of vertebrate signaling molecules which is essential for embryonic development and it implicates in carcinogenesis also. Cripto1 functions as a co-receptor for NODAL (TGF-beta member) and is essential for mesoderm as well as endoderm formation and anterior-posterior and left-right axis establishment. After executing key functions during embryonic development, it dramatically disappears in adult tissues (except stem cells). Moreover, in adult life it gets re-expressed in several type of tumors wherein it promotes cell proliferation, migration, invasion, EMT, and angiogenesis.

Specification

Reactivity

Human, Primate

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Clone Number

89627

Label

Biotin

Source

E. coli-derived recombinant human Cripto-1, Arg38-Tyr188, Accession # P13385

Specificity

Detects human and primate Cripto-1 in ELISAs. In ELISAs, this antibody does not cross-react with recombinant mouse Cripto-1, recombinant human (rh) EGF, rhTGF-alpha, rhTGF-beta 1, rhTGF-beta 1.2, rhTGF-beta 2, rhTGF-beta 3, or rhCryptic.

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Application

ELISA

Full Name

Teratocarcinoma-derived Growth Factor/Cripto Growth Factor

Alternative Names

CFC-2; CR; Cripto; Cripto-1 growth factor; Cripto-1; CRIPTOCRGF; Epidermal growth factor-like cripto protein CR1; TDGF1; TDGF-1; teratocarcinoma-derived growth factor 1

Entrez Gene IDs/Gene IDs

6997 (Human); 21667 (Mouse)

Endotoxin

<0.10 EU/μg by the LAL method.

Storage

At -20°C for one year. After reconstitution , at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

For research or further manufacturing use only. Not for use in humans.