Product Code: CB0836
Catalog Number | Unit Size | Price |
---|---|---|
CB0836-25 ug | 25 ug | Online Inquiry |
CB0836-100 ug | 100 ug | Online Inquiry |
Description
Cripto-1 (teratocarcinoma-derived growth factor-1) is the original member of EGF-cripto-1-FRL-1-cryptic (CFC) family of vertebrate signaling molecules which is essential for embryonic development and it implicates in carcinogenesis also. Cripto1 functions as a co-receptor for NODAL (TGF-beta member) and is essential for mesoderm as well as endoderm formation and anterior-posterior and left-right axis establishment. After executing key functions during embryonic development, it dramatically disappears in adult tissues (except stem cells). Moreover, in adult life it gets re-expressed in several type of tumors wherein it promotes cell proliferation, migration, invasion, EMT, and angiogenesis.
Specification