Human Cripto-1 Antibody, Unconjugated

Product Code: CB0836

Catalog Number Unit Size Price
CB0836-25 ug 25 ug Online Inquiry
CB0836-100 ug 100 ug Online Inquiry

Description

Cripto-1 (teratocarcinoma-derived growth factor-1) is the original member of EGF-cripto-1-FRL-1-cryptic (CFC) family of vertebrate signaling molecules which is essential for embryonic development and it implicates in carcinogenesis also. Cripto1 functions as a co-receptor for NODAL (TGF-beta member) and is essential for mesoderm as well as endoderm formation and anterior-posterior and left-right axis establishment. After executing key functions during embryonic development, it dramatically disappears in adult tissues (except stem cells). Moreover, in adult life it gets re-expressed in several type of tumors wherein it promotes cell proliferation, migration, invasion, EMT, and angiogenesis.

Specification

Reactivity
Human
Clonality
Polyclonal
Host
Goat
Isotype
IgG
Label
Unconjugated
Source
E. coli-derived recombinant human Cripto-1, Arg38-Tyr188, Accession # P13385
Specificity
Detects human Cripto-1 in direct ELISAs and Western Blots. In direct ELISAs, less than 1% cross-reactivity with recombinant mouse Cripto is observed.
Purification
Antigen Affinity-purified
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Small pack size is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Application
Western Blot
Full Name
Teratocarcinoma-derived Growth Factor/Cripto Growth Factor
Alternative Names
CFC-2; CR; Cripto; Cripto-1 growth factor; Cripto-1; CRIPTOCRGF; Epidermal growth factor-like cripto protein CR1; TDGF1; TDGF-1; teratocarcinoma-derived growth factor 1
Entrez Gene IDs/Gene IDs
6997 (Human); 21667 (Mouse)
Endotoxin
<0.10 EU/μg by the LAL method.
Storage
At -20°C for one year. After reconstitution , at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
For research or further manufacturing use only. Not for use in humans.

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