Human CD30/TNFRSF8 Antibody, Unconjugated

Product Code: CB0824

Catalog Number	Unit Size	Price
CB0824-25 ug	25 ug	Online Inquiry
CB0824-500 ug	500 ug	Online Inquiry

Description

Human CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. CD30 is the receptor for TNFSF8/CD30L. The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation, and apoptotic cell death.
CD30 can interact with TRAF2 and TRAF5 to mediate signal transduction of NF-kappa-B activation. CD30 may play a role in the regulation of cellular growth and transformation of activated lymphoblasts. CD30 is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect against autoimmunity.

Specification

Reactivity

Human

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Clone Number

81316

Label

Unconjugated

Source

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human CD30/TNFRSF8, Phe19-Lys379, Accession # P28908

Specificity

Detects human CD30/TNFRSF8 in direct ELISAs and Western Blots. In direct ELISAs and Western Blots, no cross-reactivity with recombinant human (rh) 4-1BB, rhCD27, recombinant mouse CD30, rhCD40, rhDR3, rhDR6, rhFas, rhGITR, rhHVEM, rhLT beta R, rhNGF R, rhOPG, rhRANK, rhTNF RI, or rhTNF RII is observed.

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Small pack size is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Application

Western Blot; ELISA

Alternative Names

CD30 antigen; CD30; CD30KI-1; CD30L receptor; cytokine receptor CD30; D1S166EKi-1; Ki-1 antigen; Lymphocyte activation antigen CD30; TNFRSF8; tumor necrosis factor receptor superfamily member 8; tumor necrosis factor receptor superfamily, member 8

Entrez Gene IDs/Gene IDs

943 (Human); 21941 (Mouse); 25069 (Rat)

Endotoxin

<0.10 EU/μg by the LAL method.

Storage

At -20°C for one year. After reconstitution , at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

For research or further manufacturing use only. Not for use in humans.