Human Activin RIIB Antibody

Product Code: CB0805

Catalog Number	Unit Size	Price
CB0805-25 ug	25 ug	Online Inquiry
CB0805-100 ug	100 ug	Online Inquiry

Description

Members of the TGF-β superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction. Activin receptor type IIB is a type II receptor that mediates multiple signals from TGF‑β family members, including Activin, Nodal, Bmp7, Gdf1, Gdf3, Myostatin (Gdf8), and Gdf11.

Specification

Reactivity

Human

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Source

Mouse myeloma cell line NS0-derived recombinant human Activin RIIB, Ser19-Thr134, Accession # CAA54671

Specificity

Detects human Activin RIIB in direct ELISAs and Western Blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse Activin RIIB is observed, and less than 1% cross-reactivity with recombinant human (rh) Activin RIIA, rhActivin RIA, and rhActivin RIB is observed.

Purification

Antigen Affinity-purified

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Small pack size is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Application

Western Blot; Immunohistochemistry; Blockade of Receptor-ligand Interaction

Full Name

Activin Receptor IIB

Alternative Names

activin A receptor, type IIB; Activin receptor type IIB; activin receptor type-2B; Activin RIIB; ActivinRIIB; ACTRIIB; ActR-IIB; ACVR2B; EC 2.7.11; EC 2.7.11.30; MGC116908

Entrez Gene IDs/Gene IDs

93 (Human); 11481 (Mouse)

Endotoxin

<0.10 EU/μg by the LAL method.

Storage

At -20°C for one year. After reconstitution , at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

For research or further manufacturing use only. Not for use in humans.