Human Activin RIB/ALK-4 Antibody, Unconjugated

Product Code: CB0802

Catalog Number	Unit Size	Price
CB0802-25 ug	25 ug	Online Inquiry
CB0802-500 ug	500 ug	Online Inquiry

Description

Activin RIB, also known as ALK4, is a glycosylated type I receptor in the superfamily of TGF-beta serine/threonine kinase receptors. Mature human Activin RIB consists of a 103-amino-acid (aa) extracellular domain (ECD), a 23 aa transmembrane segment, and a 356 aa cytoplasmic region that includes the kinase domain. It shares 25% - 35% aa sequence identity with other human type I receptors Activin RIA, Activin RIC, BMPR-IA, BMPR-IB, and TGF-beta R1. Activin RIB plays a role in multiple growth and differentiation processes, including embryonic cell fate and axis determination, cell proliferation and apoptosis, and tumorigenesis.

Specification

Reactivity

Human

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Clone Number

126822

Label

Unconjugated

Source

Mouse myeloma cell line NS0-derived recombinant human Activin RIB/ALK-4, Ser24-Glu126, Accession # AAA60556

Specificity

Detects human Activin RIB/ALK-4 in direct ELISAs and Western Blots. In direct ELISAs, this antibody does not cross-react with recombinant human (rh) Activin RIA, rhActivin RIIA, or rhActivin RIIB.

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Small pack size is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Application

Western Blot; Blockade of Receptor-ligand Interaction

Full Name

Activin Receptor IB

Alternative Names

activin A receptor, type IB; Activin receptor type IB; Activin receptor-like kinase 4; Activin RIB; ActivinRIB; ACTRIB; ACVR1B; ACVRLK4ACTR-IB; ALK4; ALK-4; ALK4activin A receptor, type II-like kinase 4; EC 2.7.11; EC 2.7.11.30; Serine/threonine-protein kinase receptor R2; SKR2activin receptor type-1B

Entrez Gene IDs/Gene IDs

91 (Human); 11479 (Mouse)

Endotoxin

<0.10 EU/μg by the LAL method.

Storage

At -20°C for one year. After reconstitution , at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

For research or further manufacturing use only. Not for use in humans.