Human Activin RIB/ALK-4 Antibody, Unconjugated

Product Code: CB0801

Catalog Number	Unit Size	Price
CB0801-25 ug	25 ug	Online Inquiry
CB0801-100 ug	100 ug	Online Inquiry

Description

Activin RIB, also known as ALK4, is a glycosylated type I receptor in the superfamily of TGF-beta serine/threonine kinase receptors. Mature human Activin RIB consists of a 103-amino-acid (aa) extracellular domain (ECD), a 23 aa transmembrane segment, and a 356 aa cytoplasmic region that includes the kinase domain. It shares 25% - 35% aa sequence identity with other human type I receptors Activin RIA, Activin RIC, BMPR-IA, BMPR-IB, and TGF-beta R1. Activin RIB plays a role in multiple growth and differentiation processes, including embryonic cell fate and axis determination, cell proliferation and apoptosis, and tumorigenesis.

Specification

Reactivity

Human

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Label

Unconjugated

Source

Mouse myeloma cell line NS0-derived recombinant human Activin RIB, Leu32-Glu126, Accession # AAA60556

Specificity

Detects human Activin RIB/ALK-4 in direct ELISAs and Western Blots. In direct ELISAs, approximately 20% cross-reactivity with recombinant human (rh) Activin RIA is observed and less than 2% cross-reactivity with rhActivin RIIA and rhActivin RIIB is observed.

Purification

Antigen Affinity-purified

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Small pack size is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Application

Western Blot; Blockade of Receptor-ligand Interaction; Knockout Validated

Full Name

Activin Receptor IB

Alternative Names

activin A receptor, type IB; Activin receptor type IB; Activin receptor-like kinase 4; Activin RIB; ActivinRIB; ACTRIB; ACVR1B; ACVRLK4ACTR-IB; ALK4; ALK-4; ALK4activin A receptor, type II-like kinase 4; EC 2.7.11; EC 2.7.11.30; Serine/threonine-protein kinase receptor R2; SKR2activin receptor type-1B

Entrez Gene IDs/Gene IDs

91 (Human); 11479 (Mouse)

Endotoxin

<0.10 EU/μg by the LAL method.

Storage

At -20°C for one year. After reconstitution , at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

For research or further manufacturing use only. Not for use in humans.