A 83-01

Product Code: GFC0657

Catalog Number	Unit Size	Price
GFC0657-10 mg	10 mg	Online Inquiry
GFC0657-50 mg	50 mg	Online Inquiry

Description

Selective inhibitor of TGF-βRI, ALK4 and ALK7. A 83-01 blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Only weakly inhibits ALK-1, -2, -3, -6 and MAPK activity. More potent than SB 431542. A 83-01 inhibits differentiation of rat induced pluripotent stem cells (riPSCs) and increases clonal expansion efficiency. Helps maintain homogeneity and long-term in vitro self-renewal of human iPSCs. Also promotes neural differentiation of hPSCs as part of a chemical cocktail.
A 83-01 synthesized to Ancillary Material Grade also available.

Specification

Chemical Name

3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide

Formula

C25H19N5S

Molecular Weight

421.52

Purity

≥98% (HPLC)

CAS No.

909910-43-6

PubChem

16218924

InChi Key

HIJMSZGHKQPPJS-UHFFFAOYSA-N

SMILES String

S=C(NC5=CC=CC=C5)N(N=C3C4=NC(C)=CC=C4)C=C3C2=CC=NC1=CC=CC=C12

Storage

Store at -20°C. Store under desiccating conditions.

For research or further manufacturing use only. Not for use in humans.