Y-27632 dihydrochloride

Product Code: GFC0654

Catalog Number	Unit Size	Price
GFC0654-1 mg	1 mg	Online Inquiry
GFC0654-10 mg	10 mg	Online Inquiry
GFC0654-50 mg	50 mg	Online Inquiry

Description

Y-27632 dihydrochloride is a selective ROCK inhibitor. Increases survival rate of human embryonic stem (hES) cells and iPSC undergoing cryopreservation. Used in combination with CHIR99021, RepSox, Forskolin, SP 600125, Go 6983 and VPA to reprogram fibroblasts to mature neurons. Also optimizes naive human pluripotent stem cell growth and viability following naive cell derivation from primed ESCs and iPSCs using naive human stem cell medium (NHSM). Used as component of growth media for urothelial organoids. Also used in a protocol to generate brain organoids from human iPSCs. Cell-permeable, orally bioavailable and active in vivo.
Y-27632 synthesized to cGMP guidelines also available.

Specification

Alternative Name

y27632, Y-27632 2HCl, ROCK inhibitor, ROCK1 inhibitor

Chemical Name

trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride

Formula

C14H21N3O.2HCl

Molecular Weight

320.26

Purity

≥98% (HPLC)

CAS No.

129830-38-2

PubChem

14801906

InChi Key

VJGZNBYDSDEOED-FJSYBICCSA-N

SMILES String

N[C@H](C)[C@@]1([H])CC[C@H]([C@](NC2=CC=NC=C2)=O)CC1.Cl.Cl

Storage

Store at +4°C. Store under desiccating conditions.

For research or further manufacturing use only. Not for use in humans.