Recombinant Human IL-11 Protein, CHO-derived

Product Code: GFC0599

Catalog Number	Unit Size	Price
GFC0599-10 ug	10 ug	Online Inquiry
GFC0599-50 ug	50 ug	Online Inquiry

Description

Interleukin 11 (IL-11) is a multifunctional cytokine member of the IL-6 family. IL-11 is secreted by osteoblasts, synoviocytes, fibroblasts, chondrocytes, intestinal myofibroblasts, and trophoblasts, among other cell types.
IL-11 plays an important regulatory role in hematopoiesis by stimulating growth of myeloid, erythroid and megakaryocyte progenitor cells. It also regulates bone metabolism, inhibits production of proinflammatory cytokines, and protects against gastromucosal injury.

Specification

Source

Chinese Hamster Ovary cell line, CHO-derived human IL-11 protein, Pro22-Leu199

Reactivity

Human

N-terminal Sequence

Pro22

Purity

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie Blue Staining.

Molecular Mass (Predicted)

19 kDa

SDS-PAGE

20-23 kDa, under reducing conditions.

Accession

P20809.1

Biological Activity

Measured in a cell proliferation assay using T11 mouse plasmacytoma cells. Nordan, R.P. et al. (1987) J. Immunol. 139:813. The ED50 for this effect is 0.02-0.12 ng/mL.

Endotoxin

<0.10 EU per 1 μg of the protein by the LAL method.

Application

Bioactivity

For research or further manufacturing use only. Not for use in humans.