Recombinant Human Dkk-1 Protein, C-Terminal Fragment

Product Code: GFC0588

Catalog Number	Unit Size	Price
GFC0588-50 ug	50 ug	Online Inquiry

Description

Dickkopf related protein 1 (DKK1) is a chemokine belonging to the DKK protein family, which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally thought to be a Xenopus head-forming molecule that acts as an antagonist of Wnt signaling.
DKK1 not only functions as a head inducer during development, but also regulates joint remodeling and bone formation, which indicate sits role in the pathogenesis of rheumatoid arthritis and multiple myeloma.

Specification

Source

Chinese Hamster Ovary cell line, CHO-derived human Dkk-1 protein, Asp142-His266, with a C-terminal 6-His tag

Reactivity

Human

N-terminal Sequence

Asp142

Purity

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie Blue Staining.

Molecular Mass (Predicted)

15 kDa

SDS-PAGE

17-33 kDa, reducing conditions

Accession

O94907

Biological Activity

Measured by its binding ability in a functional ELISA. When Recombinant Human LRP‑6 Fc Chimera (Catalog # 1505-LR) is immobilized onto a Goat anti-Human IgG Fc antibody coated plate, the concentration of Recombinant Human Dkk‑1 C-Terminal Fragment that produces 50% optimal binding response is 60-360 ng/mL.

Endotoxin

<0.10 EU per 1 μg of the protein by the LAL method.

Application

Bioactivity

For research or further manufacturing use only. Not for use in humans.