Recombinant Human/Mouse/Rat BMP-2 Protein, CHO-derived

Product Code: GFC0583

Catalog Number	Unit Size	Price
GFC0583-10 ug	10 ug	Online Inquiry
GFC0583-50 ug	50 ug	Online Inquiry
GFC0583-100 ug	100 ug	Online Inquiry

Description

Bone morphogenetic protein 2 (BMP-2) is multi-functional growth factors that belong to the transforming growth factor beta (TGF beta) superfamily. BMP-2 is a key regulator of embryogenesis and potent differentiation factor of embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC) towards endoderm fates. BMP-2 plays roles in the differentiation of mesenchymal cells to adipocytes, epithelial cancer EMT, chondrogenesis and regulation of neuronal and glial cell development.

Specification

Source

Chinese Hamster Ovary cell line, CHO-derived BMP-2 protein, Gln283-Arg396

Reactivity

Human/Mouse/Rat

Purity

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Molecular Mass (Predicted)

13 kDa (monomer)

SDS-PAGE

15-16 kDa, reducing conditions

Accession

P12643

Biological Activity

Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Binnerts, M.E. et al. (2004) Biochem. Biophys. Res. Commun. 315(2):272. The ED50 for this effect is 40-200 ng/mL.

Endotoxin

<0.10 EU per 1 μg of the protein by the LAL method.

Application

Bioactivity

For research or further manufacturing use only. Not for use in humans.