Recombinant Human/Mouse/Rat BMP-2, E. coli-derived

Product Code: GFC0581

Catalog Number	Unit Size	Price
GFC0581-10 ug	10 ug	Online Inquiry
GFC0581-25 ug	25 ug	Online Inquiry
GFC0581-100 ug	100 ug	Online Inquiry

Description

Bone morphogenetic protein 2 (BMP-2) is multi-functional growth factors that belong to the transforming growth factor beta (TGF beta) superfamily. BMP-2 is a key regulator of embryogenesis and potent differentiation factor of embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC) towards endoderm fates. BMP-2 plays roles in the differentiation of mesenchymal cells to adipocytes, epithelial cancer EMT, chondrogenesis and regulation of neuronal and glial cell development.

Specification

Source

E. coli-derived BMP-2 protein, Ala284-Arg396

Reactivity

Human/Mouse/Rat

N-terminal Sequence

Ala284

Purity

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Molecular Mass (Predicted)

12.8 kDa (monomer)

Accession

P12643

Biological Activity

Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Nakamura, K. et al. (1999) Exp. Cell Res. 250:351. The ED50 for this effect is 0.08-0.48 µg/mL.

Endotoxin

<0.01 EU per 1 μg of the protein by the LAL method.

Application

Bioactivity

For research or further manufacturing use only. Not for use in humans.