Human IL-15, research grade

Product Code: GFC0547

Catalog Number	Unit Size	Price
GFC0547-10 µg	10 µg	Online Inquiry
GFC0547-25 µg	25 µg	Online Inquiry

Description

Recombinant human IL-15 (interleukin 15) promotes proliferation of activated T, NK, and B cells . The regulatory cytokine IL-15 has important diverse roles in the immune system. It is structurally related to IL-2 and they share many functional characteristics. The recombinant protein is optimized for use in cell culture, differentiation studies, and functional assays.

Specification

Sample Resource

E. coli

Species

Human

Application

Human IL-15 can be used for a variety of applications, including:

Activation and expansion of NK and NKT cells.
In vitro differentiation of NK cells, e.g., from purified CD34+ cells.
In vitro T cell expansion, e.g., of naive CD8+ T cells, and T cell activation, e.g., of CTLs.

Research Grade

2×10^6 U/mg

Background Information

IL-15 is a member of the four α-helix bundle cytokine family. It is produced by different cell types, including epithelial cells, monocytes, muscle and placenta cells. IL-15 is a potent lymphoid cell growth factor. It stimulates the proliferation of activated T cells and promotes the generation of cytotoxic T lymphocytes (CTLs). IL-15 also induces the generation, proliferation, and activation of NK cells as well as B cell growth and immunoglobulin production. In addition, IL-15 is important for the maintenance of CD8+ memory T cells. For binding and signaling IL-15 uses the unique IL-15 receptor α-chain, but shares the β- and γ-chain of the IL-2 receptor.

For research or further manufacturing use only. Not for use in humans.