Recombinant Human IL-1β

Product Code: GFC0536

Catalog Number	Unit Size	Price
GFC0536-2µg	2µg	Online Inquiry
GFC0536-10µg	10µg	Online Inquiry
GFC0536-50µg	50µg	Online Inquiry
GFC0536-100µg	100µg	Online Inquiry
GFC0536-250µg	250µg	Online Inquiry
GFC0536-500µg	500µg	Online Inquiry
GFC0536-1mg	1mg	Online Inquiry

Description

IL-1β is a proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes, and other epithelial cells. Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties. These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B cell maturation and proliferation, mitogenic FGF-like activity, and the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant Human IL-1β is a 17.3 kDa protein containing 153 amino acid residues.

Specification

Sample Resource

E.coli

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Synonyms

Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)

AA Sequence

APVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS

Biological Activity

The ED50 as determined by the dose-dependent stimulation of thymidine uptake by murine D10S cells is ≤ 1.0 pg/ml, corresponding to a specific activity of ≥ 1 x 109 units/mg.

Calculated Molecular Weight

17.3 kDa

Accession Number

P01584

Gene ID

3553

Endotoxin

Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

For research or further manufacturing use only. Not for use in humans.