Human IL-2 IS, premium grade

Product Code: GFC0524

Catalog Number	Unit Size	Price
GFC0524-10 µg	10 µg	Online Inquiry
GFC0524-50 µg	50 µg	Online Inquiry
GFC0524-200 µg	200 µg	Online Inquiry
GFC0524-1000 µg	1000 µg	Online Inquiry

Description

Recombinant human IL-2 (interleukin 2) stimulates growth and differentiation of cells of the lymphoid lineage, such as T, NK, and B cells. IL-2 is a potent immunomodulatory cytokine, as it prevents autoimmunity and has key functions during infections. IL-2 IS stands for interleukin 2 "Improved Sequence", also termed aldesleukin, and is a variant of IL-2 with a serine substitution for the native cysteine at amino acid position 125. Human IL-2 IS is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays, and possesses the same biological properties as naturally occurring IL-2.

Specification

Sample Resource

E. coli

Species

Human

Application

Human IL-2 IS can be used for a variety of applications including:

In vitro activation and propagation of T cells, e.g., in combination with the T Cell Activation/Expansion Kit, human.
In vitro stimulation of cytolytic function and expansion of NK cells, e.g., using the NK Cell Activation/Expansion Kit, human.
Generation of lymphokine-activated killer (LAK) cells or cytokine-induced killer (CIK) cells.

Premium Grade

≥ 5×10^6 IU/mg (Typical activity 9×10^6 IU/mg)

Background Information

IL-2, a potent lymphoid cell growth factor, is a typical four α-helix bundle cytokine. It is produced by activated T cells, especially the CD4+ T helper cell population. It plays an important role in both the activation and maintenance of immune responses and in lymphocyte development. IL-2 promotes proliferation and differentiation of T cells, NK cells and B cells and is involved in the elimination of self-reactive T cells. IL-2 signals through a receptor complex consisting of IL-2 receptor α-chain (CD25), β- chain, and common γ-chain. The latter two are also used for IL-15 signaling.

For research or further manufacturing use only. Not for use in humans.