Product Code: GFC0532
| Catalog Number | Unit Size | Price |
|---|---|---|
| GFC0532-10µg | 10µg | Online Inquiry |
| GFC0532-50µg | 50µg | Online Inquiry |
| GFC0532-100µg | 100µg | Online Inquiry |
| GFC0532- 250µg | 250µg | Online Inquiry |
| GFC0532-500µg | 500µg | Online Inquiry |
| GFC0532-1mg | 1mg | Online Inquiry |
Description
TNF-α is a pleiotropic pro-inflammatory cytokine secreted by various cells, including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands, and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells, and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, autoimmune diseases, rheumatoid arthritis, inflammation, and diabetes. Human and murine TNF-α demonstrate significant cross-species reactivity. TNF-α exists in two forms; a type II transmembrane protein, and a mature soluble protein. The TNF-α transmembrane protein is proteolitically cleaved to yield a soluble, biologically active, 17 kDa TNF-α, which forms a non-covalently linked homotrimer in solution. Recombinant Human TNF-α is a soluble 157 amino acid protein (17.4 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.
Specification
